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KMID : 0360220170580111307
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Journal of the Korean Ophthalmological Society
2017 Volume.58 No. 11 p.1307 ~ p.1312
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Hyper-proliferation of Glial Tissues Following Autologous Internal Limiting Membrane Transplantation in Idiopathic Large Macular Holes
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Park Jong-Ho
Jung Jae-Woo
Lee Seung-Min
Park Sung-Who
Lee Ji-Eun
Byon Ik-Soo
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Abstract
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Purpose: To report three cases of glial hyper-proliferation after autologous internal limiting membrane (ILM) transplantation in idiopathic large macular holes.
Case summary: Three eyes with full thickness macular holes >500 μm underwent autologous ILM transplantation. After surgery, the macular hole was closed and foveal contour was U-shaped. Optical coherence tomography revealed long-lasting proliferation of glial cells in the fovea after the hole closure. This glial proliferation continued for 6 months, with improved visual acuity, and bump-like features of the fovea.
Conclusions: Autologous transplantation of ILM effectively induced long-lasting proliferation of glial cells, thereby achieving the closure of large macular holes. However, an abnormality of the foveal contour may develop after the hole closure in some cases.
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KEYWORD
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Autologous internal limiting membrane transplantation, Glial cell, Hyper-proliferation, Macular hole
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